
Red light therapy is a non-invasive light treatment method. It works by sending light energy to the mitochondria to stimulate cells and produce the energy required to activate a range of biochemical processes. The biological processes trigger several red light therapy benefits, such as increased collagen production, inflammation control, and pain relief among others.
Since put that way the answer can sound complex, below are simplified details on the principles of how red light therapy works.
When red light is directed to the skin of different body parts, a primary red light therapy mechanism occurs: the light is absorbed by the mitochondria.
Mitochondria are the cell organs that produce the chemical energy needed for the functioning of cells. These organs have a molecule known as cytochrome c oxidase. It is the main photoreceptor of the red and near-infrared (NIR) light.
According to research, once red and NIR light is absorbed into the cells, it stimulates several biochemical processes. These processes include:
All these processes are key in activating other intracellular activities related to cell production and survival. They also trigger tissue repair and regeneration.
Once red light is absorbed by the mitochondria and these processes are triggered, then the other red light working principles are triggered, beginning with boosted ATP production.
Adenosine triphosphate is the primary energy source for cells produced by light-stimulated mitochondria. ATP generates energy for cellular processes like tissue growth, skin healing, and skin repair.
Research has shown that higher ATP production benefits skin health by supporting fibroblast proliferation. Fibroblasts are connective tissues that are crucial for the production of collagen and other tissue fibers.
ATP also promotes the regeneration of cytokines (key proteins for cell function). The proteins support wound healing, especially through the keratinocyte growth factor process.
Collagen is vital in skin health and other tissue processes like cartilage repair and skin elasticity. It is the main protein that supports body structure.
Clinical studies on red light therapy efficacy have shown positive results for increased collagen and elastin production when cell fibroblasts are exposed to red and near-infrared light. The red light treatment also induces gene expression for different collagen types and skin fibers.
Similarly, boosted collagen synthesis from cell exposure to red light increases skin tissue repair. This leads to skin rejuvenation and regeneration.
Studies have revealed that low-level light therapy (LLLT) triggers key cell signaling pathways to increase cell production, migration, and differentiation. All three processes are vital in tissue regeneration and repair.
Also, red light therapy reduces reactive oxygen types, triggering anti-oxidant effects and reducing oxidative stress.
Enhanced blood flow is key to cell function and tissue healing. Research has shown that red light therapy supports vasodilation, the widening of blood vessels. This happens because red light causes the muscular walls of blood vessels to relax.
Red light therapy controls inflammatory responses in cell proteins. Instead, it activates anti-inflammatory responses that are key in pain relief and tissue healing.
Studies have revealed that inflammation control by RLT reduces the formation of free radicals and effectively modulates inflammatory gene expression.
Red light therapy reduces the sensitivity of pain receptors by acting on the peripheral nervous system. In addition, it triggers the release of natural pain blockers to regulate tissue and nerve sensitivity to pain.
Research has confirmed that both red and infrared light wavelengths reduce pain in people with acute joint pain from conditions like osteoarthritis.
And now that you know how red light therapy works, you certainly want to know which conditions it can help with.
Red light therapy treats many conditions through the principles of red light therapy that we have discussed above.
Here’s a summarized list of the conditions red light therapy treats, alongside the biochemical process activated by RLT to treat those conditions.

To ensure red light therapy delivers these healing actions, you must choose the right red light therapy solution for your needs.
Depending on your treatment needs, you can have red light therapy at home or in professional wellness centers like spas, saunas, gyms, salons, or healthcare centers.
There are some key differences between at-home and professional red light therapy:
If you choose at-home red light therapy, in which case you have to purchase an RLT device for home use, ensure you select the right one for your needs. Consider factors like wavelength, treatment depth, cost, and device safety.
Read the full details of how to choose a red light therapy device in our designated article.
How does red light therapy work? The science of red light therapy works by activating key biochemical processes. The first process is light absorption by mitochondria to boost cell energy. This comes with increased production of adenosine triphosphate (ATP), the main energy-supplying molecule for cells.
Other processes like increased collagen production, enhanced blood flow, and the control of pain receptors are key in cell regeneration, skin healing, pain relief, muscle recovery, and general wellness.
Knowing how red light therapy works to treat different conditions will help you choose between at-home and professional RLT. This article has given you key tips to do just that.
1. Cleveland Clinic: Arthritis.
2. NIH: Arthritis.
3. Fallon EA, Boring MA, Foster AL, et al. (2023). Prevalence of Diagnosed Arthritis – United States, 2019–2021. *MMWR Morb Mortal Wkly Rep.*, 72(41), 1101–1107.
4. Padalhin A, Chung P, Woo S. H. (2024). Phototherapy for Osteoarthritis Management: A Narrative Review. *Med Lasers*, 13(2), 82–89.
5. I-Cheng C, Chen-Ying S, Chi-Hau F, Hsu-Wei F. (2021). Preventative Treatment of Red Light-Emitting Diode Protected Osteoarthritis-like Chondrocytes from Oxidative Stress-Induced Inflammation and Promoted Matrix Gene Expression. *Journal of the Taiwan Institute of Chemical Engineers*, 127, 23–31.
6. Fan T, Li Y, Wong A.Y.L., et al. (2024). A Systematic Review and Network Meta-analysis on the Optimal Wavelength of Low-Level Light Therapy (LLLT) in Treating Knee Osteoarthritis Symptoms. *Aging Clin Exp Res*, 36, 203.
7. Stelian J, Gil I, Habot B, et al. (1992). Improvement of Pain and Disability in Elderly Patients with Degenerative Osteoarthritis of the Knee Treated with Narrow-band Light Therapy. *J Am Geriatr Soc.*, 40(1), 23–26.
8. Tong J, Subbiah S.K., Rampal S., et al. (2024). Effect of 660-nm LED Photobiomodulation on the Proliferation and Chondrogenesis of Meniscus-Derived Stem Cells (MeSCs). *Sci Rep*, 14, 19735.
9. Oliveira S, Andrade R, Hinckel BB, et al. (2021). In Vitro and In Vivo Effects of Light Therapy on Cartilage Regeneration for Knee Osteoarthritis: A Systematic Review. *CARTILAGE*, 13(2), 1700S–1719S.
10. Hamblin MR. (2013). Can Osteoarthritis Be Treated with Light? *Arthritis Res Ther.*, 15(5), 120.