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How Does Red Light Therapy Work? Key Research-Backed Insights
Date
Updated January 7, 2025
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12 Min
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Article by
David Johnson
Red light therapy research has shown positive outcomes for medical and esthetic treatments. The non-invasive phototherapy is effective for skin care, joint pain relief, wound healing, muscle recovery, and overall well-being.
A compact and affordable handheld infrared lamp
But exactly how does red light therapy work to achieve these benefits?

We have science-proven answers to that question in this article.

Plus, we tell you which conditions RLT helps with and how to decide between at-home red light therapy and professional RLT.

Let’s start with our key question: How does red light therapy work?

How Red Light Therapy Works?

Red light therapy is a non-invasive light treatment method. It works by sending light energy to the mitochondria to stimulate cells and produce the energy required to activate a range of biochemical processes. The biological processes trigger several red light therapy benefits, such as increased collagen production, inflammation control, and pain relief among others. 

Since put that way the answer can sound complex, below are simplified details on the principles of how red light therapy works.

1. RLT is Absorbed by Mitochondria to Boost Cell Energy

When red light is directed to the skin of different body parts, a primary red light therapy mechanism occurs: the light is absorbed by the mitochondria. 

Mitochondria are the cell organs that produce the chemical energy needed for the functioning of cells. These organs have a molecule known as cytochrome c oxidase. It is the main photoreceptor of the red and near-infrared (NIR) light.

According to research, once red and NIR light is absorbed into the cells, it stimulates several biochemical processes. These processes include:

  • The breakdown of repressive nitric oxide in order to boost enzyme activity.
  • Enhanced mitochondrial electron transport chain. 
  • Boosted mitochondrial respiration.
  • Increased production of adenosine triphosphate (ATP).

All these processes are key in activating other intracellular activities related to cell production and survival. They also trigger tissue repair and regeneration.

Once red light is absorbed by the mitochondria and these processes are triggered, then the other red light working principles are triggered, beginning with boosted ATP production.

 

2. Boosting the Production of Adenosine Triphosphate (ATP)

Adenosine triphosphate is the primary energy source for cells produced by light-stimulated mitochondria. ATP generates energy for cellular processes like tissue growth, skin healing, and skin repair.

Research has shown that higher ATP production benefits skin health by supporting fibroblast proliferation. Fibroblasts are connective tissues that are crucial for the production of collagen and other tissue fibers. 

ATP also promotes the regeneration of cytokines (key proteins for cell function). The proteins support wound healing, especially through the keratinocyte growth factor process.

 

3. Enhancing Collagen Production and Synthesis

Collagen is vital in skin health and other tissue processes like cartilage repair and skin elasticity. It is the main protein that supports body structure.

Clinical studies on red light therapy efficacy have shown positive results for increased collagen and elastin production when cell fibroblasts are exposed to red and near-infrared light. The red light treatment also induces gene expression for different collagen types and skin fibers.

Similarly, boosted collagen synthesis from cell exposure to red light increases skin tissue repair. This leads to skin rejuvenation and regeneration.

 

4. Supporting Cell Function and Reducing Oxidative Stress

Studies have revealed that low-level light therapy (LLLT) triggers key cell signaling pathways to increase cell production, migration, and differentiation. All three processes are vital in tissue regeneration and repair.

Also, red light therapy reduces reactive oxygen types, triggering anti-oxidant effects and reducing oxidative stress.

 

5. Increasing Blood Flow

Enhanced blood flow is key to cell function and tissue healing. Research has shown that red light therapy supports vasodilation, the widening of blood vessels. This happens because red light causes the muscular walls of blood vessels to relax.

 

6. Activating Anti-inflammation Responses in Cells

Red light therapy controls inflammatory responses in cell proteins. Instead, it activates anti-inflammatory responses that are key in pain relief and tissue healing.

Studies have revealed that inflammation control by RLT reduces the formation of free radicals and effectively modulates inflammatory gene expression.

 

7. Blocking Pain Receptors and Triggering Natural Pain Blockers

Red light therapy reduces the sensitivity of pain receptors by acting on the peripheral nervous system. In addition, it triggers the release of natural pain blockers to regulate tissue and nerve sensitivity to pain.

Research has confirmed that both red and infrared light wavelengths reduce pain in people with acute joint pain from conditions like osteoarthritis.

And now that you know how red light therapy works, you certainly want to know which conditions it can help with.

What Conditions Can RLT Help With?

Red light therapy treats many conditions through the principles of red light therapy that we have discussed above.

Here’s a summarized list of the conditions red light therapy treats, alongside the biochemical process activated by RLT to treat those conditions.

To ensure red light therapy delivers these healing actions, you must choose the right red light therapy solution for your needs.

Choosing the Right RLT Solution for Your Needs

Depending on your treatment needs, you can have red light therapy at home or in professional wellness centers like spas, saunas, gyms, salons, or healthcare centers.

There are some key differences between at-home and professional red light therapy:

1. Device Size and Coverage

  • At-home therapy uses mostly handheld or portable devices, like masks, wands, wraps, and small panels. These devices have fewer light-emitting diodes and are generally used for localized treatment that covers a specific area. Note, however, that larger panels can be used at home to treat areas like the back and deliver broad whole-body light illumination. 
  • Professional therapy devices can be handheld for small-area specialized treatment.  They can also be full-body devices with thousands of LEDs for comprehensive single-session therapy.

2. Power Intensity

  • At-home therapy devices usually have lower power intensity. As such, you must use them regularly for longer sessions to achieve the desired effects.
  • Professional therapy devices, like large panels and beds, have higher power intensity and deliver stronger irradiance. So, they have deeper penetration in shorter session time.

3. Wavelength and Advanced Technology

  • At-home therapy devices offer red (630-660nm) and near-infrared (810-850) wavelengths. While some brands like the RedLiteX use medical-grade materials, others may not have this safety quality.
  • Professional therapy devices are often high-end. Although they use the same wavelengths, they may have varied wavelength technology for specific treatments. They also have special settings like pulsed light, which can also be included in at-home panels.

4. Cost 

  • At-home therapy devices usually cost less, between a few hundred dollars to a little over a thousand dollars, depending on the size.
  • Professional therapy devices cost thousands of dollars, so customers pay high per-session charges on top of the charge for professional service by an expert.

5. Combined Therapies

  • At-home therapy devices usually deliver clean red light without additional products.
  • Professional centers often combine red light therapy with skin products for issues like cellulite.  They may also combine phototherapy with massages or infrared saunas.

If you choose at-home red light therapy, in which case you have to purchase an RLT device for home use, ensure you select the right one for your needs. Consider factors like wavelength, treatment depth, cost, and device safety.

Read the full details of how to choose a red light therapy device in our designated article.

Quick Summary

How does red light therapy work? The science of red light therapy works by activating key biochemical processes. The first process is light absorption by mitochondria to boost cell energy. This comes with increased production of adenosine triphosphate (ATP), the main energy-supplying molecule for cells.

Other processes like increased collagen production, enhanced blood flow, and the control of pain receptors are key in cell regeneration, skin healing, pain relief, muscle recovery, and general wellness.

Knowing how red light therapy works to treat different conditions will help you choose between at-home and professional RLT. This article has given you key tips to do just that.

Sources

1. Cleveland Clinic: Arthritis.

2. NIH: Arthritis.

3. Fallon EA, Boring MA, Foster AL, et al. (2023). Prevalence of Diagnosed Arthritis – United States, 2019–2021. *MMWR Morb Mortal Wkly Rep.*, 72(41), 1101–1107.

4. Padalhin A, Chung P, Woo S. H. (2024). Phototherapy for Osteoarthritis Management: A Narrative Review. *Med Lasers*, 13(2), 82–89.

5. I-Cheng C, Chen-Ying S, Chi-Hau F, Hsu-Wei F. (2021). Preventative Treatment of Red Light-Emitting Diode Protected Osteoarthritis-like Chondrocytes from Oxidative Stress-Induced Inflammation and Promoted Matrix Gene Expression. *Journal of the Taiwan Institute of Chemical Engineers*, 127, 23–31.

6. Fan T, Li Y, Wong A.Y.L., et al. (2024). A Systematic Review and Network Meta-analysis on the Optimal Wavelength of Low-Level Light Therapy (LLLT) in Treating Knee Osteoarthritis Symptoms. *Aging Clin Exp Res*, 36, 203.

7. Stelian J, Gil I, Habot B, et al. (1992). Improvement of Pain and Disability in Elderly Patients with Degenerative Osteoarthritis of the Knee Treated with Narrow-band Light Therapy. *J Am Geriatr Soc.*, 40(1), 23–26.

8. Tong J, Subbiah S.K., Rampal S., et al. (2024). Effect of 660-nm LED Photobiomodulation on the Proliferation and Chondrogenesis of Meniscus-Derived Stem Cells (MeSCs). *Sci Rep*, 14, 19735.

9. Oliveira S, Andrade R, Hinckel BB, et al. (2021). In Vitro and In Vivo Effects of Light Therapy on Cartilage Regeneration for Knee Osteoarthritis: A Systematic Review. *CARTILAGE*, 13(2), 1700S–1719S.

10. Hamblin MR. (2013). Can Osteoarthritis Be Treated with Light? *Arthritis Res Ther.*, 15(5), 120.

Article by
David Johnson
David Johnson is a co-founder of RedliteX and a healthcare professional with extensive experience in red light therapy. He specializes in the research and application of red light therapy panels for therapeutic and wellness purposes, with a deep understanding of the science behind light-based treatments. Committed to education and evidence-based insights, he focuses on how red light therapy can support healing, pain management, recovery, and overall well-being.

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